Globálny slovník portálu IMED

Pojem: 
Extrakraniální radioterapie a radiochirurgie
Definícia: 

Extrakraniální stereotaktická radioterapie/radiochirurgie (SBRT – stereotactic body radiotherapy) využívá velmi přesné aplikace vysoké jednotlivé dávky záření v malém počtu frakcí. Díky stále lepší vybavenosti radioterapeutických pracovišť z hlediska možností obrazové navigace a fixace pacientů lze stereotaktický přístup využít prakticky ve všech anatomických lokalitách. S výhodou nalézá uplatnění zvláště při léčbě nádorových ložisek v plících, játrech, dutině břišní či pánvi a ve skeletu.

Kľúčové slovo: 
Radiochirurgie
Pojem: 
syndróm nedostatku testosterónu - TDS
Definícia: 

<div>TDS (testosterone deficiency syndrome) je definovan&yacute; ako klinick&yacute; a biochemick&yacute; syndr&oacute;m, ku ktor&eacute;mu doch&aacute;dza v procese starnutia mužov. Nedostatok testoster&oacute;nu u postihnut&yacute;ch mužov nepriaznivo vpl&yacute;va na funkcie viacer&yacute;ch org&aacute;nov&yacute;ch syst&eacute;mov. Vedie k podstatn&eacute;mu zhor&scaron;eniu kvality života. U mužov medzi 40 - 70 rokmi kles&aacute; biologicky akt&iacute;vny testoster&oacute;n v s&eacute;re približne o 1,2 % ročne.</div>

Pojem: 
Spolupráca endokrinológa a oftalmológa pri endokrinnej orbitopatii
Definícia: 

Práca sa venuje návodu, ako by mala vyzerať spolupráca oftalmológa s endokrinológom a zbytočným chybám, ku ktorým často zbytočne dochádza.

Kľúčové slovo: 
hrúbka extraokulárnych svalov
vnútroočný tlak
epidemiologické faktory
Endokrinná orbitopatia
farebná dopplerovská ultrasonografia
Pojem: 
Epithelial-mesenchymal transition (EMT) – epiteliálno-mezenchymálny prechod
Definícia: 

<p>
<pre>je fyziologick&yacute; proces prebiehaj&uacute;ci v embryogen&eacute;ze a pri hojen&iacute; r&aacute;n. Prejavuje sa aj v patologick&yacute;ch procesoch tumorigen&eacute;zy, ako s&uacute; inici&aacute;cia
a progresia n&aacute;dorov. Z&aacute;kladnou vlastnosťou EMT je strata epitelovej morfol&oacute;gie bunky a z&iacute;skanie vlastnost&iacute;, ktor&eacute; s&uacute; podobn&eacute; fibroblastom. Je
to sp&ocirc;soben&eacute; najm&auml; zn&iacute;ženou expresiou E-kadher&iacute;nu v d&ocirc;sledku aktiv&aacute;cie transkripčn&eacute;ho komplexu TCF/LEF s b-katen&iacute;nom, ako aj transkripčn&yacute;ch
faktorov Twist, Snai1, ZEB, ktor&yacute;ch aktivita koreluje s fenotypom kmeňov&yacute;ch buniek.</pre>
</p>

Kľúčové slovo: 
iniciácia a progresia nádorov
Pojem: 
Nasýtené mastné kyseliny (NMK)
Definícia: 

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<p class=\"MsoNormal\"><strong><span style=\"font-size: 12pt; line-height: 115%; font-family: &quot;Times New Roman&quot;,&quot;serif&quot;;\"><span></span></span></strong><span style=\"font-size: 12pt; line-height: 115%; font-family: &quot;Times New Roman&quot;,&quot;serif&quot;;\">maj&uacute; druh&yacute; najvy&scaron;&scaron;&iacute; aterog&eacute;nny potenci&aacute;l. NMK nie s&uacute; len v&nbsp;živoč&iacute;&scaron;nych tukoch (maslo 62 %, bravčov&aacute; masť 40 %), ale aj v&nbsp;niektor&yacute;ch rastlinn&yacute;ch tukoch (kokosov&yacute; a&nbsp;palmov&yacute; olej). Zatiaľ st&aacute;le ch&yacute;ba legislat&iacute;va určuj&uacute;ca povinnosť v&yacute;robcu jasne deklarovať množstvo TFMK a&nbsp;NMK v&nbsp;potravin&aacute;ch.</span></p>

Kľúčové slovo: 
aterogénny potenciál
Pojem: 
omega 3 nenasýtené mastné kyseliny
Definícia: 

<p>
Sarkop&eacute;nia- &Uacute;bytok svalovej hmoty sprev&aacute;dzan&yacute; zmen&scaron;en&iacute;m svalovej sily a&nbsp; v&yacute;konnosti.</p>
<p>
&nbsp;Sarkop&eacute;nia &nbsp;1, stupňa je &uacute;bytok svalovej hmoty v&nbsp;rozmedz&iacute; -1&nbsp; až 2 smerodajn&eacute; odch&yacute;lky od priemeru &nbsp;</p>
<p>
hodn&ocirc;t&nbsp; mlad&yacute;ch ľud&iacute;.&nbsp; Pri sarkop&eacute;nii &nbsp;2 stupňa je tento &uacute;bytok v&auml;č&scaron;&iacute; ako 2 smerodajn&eacute; odch&yacute;lky</p>
<p>
&nbsp;</p>
<p>
Omega 3 &nbsp;nenas&yacute;ten&yacute; mastn&eacute; kyseliny &nbsp;Skupina mastn&yacute;ch kysel&iacute;n&nbsp; )PUFA -Poly&nbsp; Unsaturated&nbsp; Fatty Acids ) sa viacer&yacute;mi dvojit&yacute;m v&auml;zbami medzi uhl&iacute;kmi, z&nbsp;ktor&yacute;ch jedna &nbsp;je&nbsp; na 3. uhl&iacute;ku. Patria medzi ne EPA (kyselina eikosapent&eacute;noov&aacute;) a DHA (kyselina dokosahex&eacute;nov&aacute;)</p>

Pojem: 
Variabilné hodnoty krvného tlaku
Definícia: 

<p>
Variabilita krvn&eacute;ho tlaku sa hodnot&iacute; podľa zmien TK od merania k meraniu (pri ABPM, 24-hod &bdquo;tlakov&yacute; Holter&ldquo;), od dňa ku dňu (pri dom&aacute;com meran&iacute;), od vizity k vizite (pri pravidelnom vy&scaron;etrovan&iacute; v ambulanci&aacute;ch).</p>

Kľúčové slovo: 
tlakový Holter
Pojem: 
Progestíny
Definícia: 

<p>
s&uacute; syntetick&eacute; formy progester&oacute;nu odvoden&eacute; od 19-nortestoster&oacute;nu, 17-0H progester&oacute;nov&yacute;ch deriv&aacute;tov alebo 19-norprogester&oacute;nu. Jestvuje veľa typov progest&iacute;nov, ktor&eacute; sa l&iacute;&scaron;ia podľa &uacute;činkov a afinity k receptorom estrog&eacute;nu, progester&oacute;nu a androg&eacute;nov&yacute;m receptorom. Nov&scaron;ie progest&iacute;ny s&uacute; selekt&iacute;vne v tom zmysle, že dostatočne inhibuj&uacute; ovul&aacute;ciu a endometri&aacute;lnu hypertrofiu, ale ich androg&eacute;nny efekt je značne redukovan&yacute;. Dokonca kombin&aacute;cia estrog&eacute;nu s drospiren&oacute;nom (progest&iacute;n odvoden&yacute; od spironolakt&oacute;nu) m&aacute; antiandrog&eacute;nny a diuretick&yacute; &uacute;činok&nbsp;&nbsp;</p>

Kľúčové slovo: 
hormonálna antikoncepcia
Pojem: 
biomarker
Definícia: 

<p>
je molekula (napr&iacute;klad prote&iacute;n, metabolit či nukleov&aacute; kyselina) použ&iacute;van&aacute; ako indik&aacute;tor určit&eacute;ho fyziologick&eacute;ho alebo patologick&eacute;ho stavu organizmu. Ide&aacute;lny biomarker by mal disponovať vysokou senzitivitou, &scaron;pecifitou, mal by mať vysok&uacute; v&yacute;povedn&uacute; hodnotu, dobr&eacute; pozit&iacute;vne a negat&iacute;vne predikt&iacute;vne hodnoty, mal by byť ľahko interpretovan&yacute; v klinickej praxi a dobre merateľn&yacute; v biologick&yacute;ch vzork&aacute;ch pacienta.</p>

Kľúčové slovo: 
proteín
biomarker
Pojem: 
proteomika
Definícia: 

<p>
je vedn&aacute; discipl&iacute;na zaoberaj&uacute;ca sa prote&iacute;nmi v&nbsp;živ&yacute;ch organizmoch, ich &scaron;trukt&uacute;rou, modifik&aacute;ciami, funkciou a&nbsp;zast&uacute;pen&iacute;m v&nbsp;bunk&aacute;ch. Na &scaron;t&uacute;dium prote&iacute;nov sa využ&iacute;va množstvo techn&iacute;k, od elektrofor&eacute;zy cez plynov&uacute; chromatografiu až po hmotnostn&uacute; spektrometriu. V&nbsp;stanovovan&iacute; prote&iacute;nov&eacute;ho profilu buniek sa využ&iacute;va 2D elektrofor&eacute;za, v&nbsp;ktorej s&uacute; prote&iacute;ny&nbsp; separovan&eacute; podľa veľkosti v&nbsp;jednom smere a&nbsp;podľa elektrochemick&yacute;ch vlastnost&iacute; v&nbsp;smere druhom. Takto rozdelen&eacute; prote&iacute;ny je možn&eacute; identifikovať pomocou prote&iacute;nov&yacute;ch datab&aacute;z. Sekvenciu aminokysel&iacute;n v&nbsp;nezn&aacute;mom prote&iacute;ne je možn&eacute; určiť pomocou tandemovej hmotnostnej spektrometrie. &Scaron;t&uacute;diom zmien expresie prote&iacute;nov v&nbsp;bunk&aacute;ch a&nbsp;&scaron;t&uacute;diom reakci&iacute; prote&iacute;nov medzi sebou proteomika v&yacute;razne prispieva k&nbsp;hľadaniu metabolick&yacute;ch dr&aacute;h, k&nbsp;v&yacute;voju nov&yacute;ch liečiv či k&nbsp;&scaron;t&uacute;diu biomarkerov (Cit. podľa<span style=\"font-size: 12px;\">&nbsp;Trubenov&aacute;, B. Syst&eacute;mov&aacute; biol&oacute;gia. </span><em style=\"font-size: 12px;\">Biol&oacute;gia ekon&oacute;mia ch&eacute;mia.</em><span style=\"font-size: 12px;\"> 2009;13(3-4)</span><em style=\"font-size: 12px;\">, </em><span style=\"font-size: 12px;\">str.18, ISSN 1338-1024.)</span></p>

Kľúčové slovo: 
proteín
hmotnostná spektrometria
chromatografia
elektroforéza
Pojem: 
metabolomika
Definícia: 

<p>
je vedn&aacute; discipl&iacute;na, ktor&aacute; sa zaober&aacute; &scaron;t&uacute;diom mal&yacute;ch molek&uacute;l v&nbsp;kontexte biochemick&yacute;ch procesov. Jedn&aacute; sa o&nbsp;metabolity -&nbsp;zl&uacute;čeniny men&scaron;ie ako 1500 Daltonov, ktor&eacute; sa nach&aacute;dzaj&uacute; v&nbsp;bunk&aacute;ch. Patria sem sacharidy, lipidy, aminokyseliny, organick&eacute; kyseliny a&nbsp;mnoh&eacute; in&eacute; l&aacute;tky. Po izol&aacute;cii metabolitov z&nbsp;buniek sa tieto separuj&uacute;, najčastej&scaron;ie pomocou kvapalinovej alebo plynovej chromatografie, a&nbsp;identifikuj&uacute; pomocou nukle&aacute;rnej magnetickej rezonancie alebo hmotnostnej spektrometrie. V&yacute;sledkom je metabolick&yacute; profil buniek &ndash; zoznam pr&iacute;tomn&yacute;ch metabolitov a&nbsp;ich relat&iacute;vne zast&uacute;penie v&nbsp;bunke. Metabolomick&eacute; profilovanie sa okrem prim&aacute;rneho v&yacute;skumu využ&iacute;va v&nbsp;medic&iacute;nskej diagnostike, pretože je pomerne jednoduch&eacute; a&nbsp;tiež finančne nen&aacute;ročn&eacute;&nbsp;<span style=\"font-size: 12px;\">(Cit. podľa</span><span style=\"font-size: 12px;\">&nbsp;Trubenov&aacute;, B. Syst&eacute;mov&aacute; biol&oacute;gia.&nbsp;</span><em style=\"font-size: 12px;\">Biol&oacute;gia ekon&oacute;mia ch&eacute;mia.</em><span style=\"font-size: 12px;\">&nbsp;2009;13(3-4)</span><em style=\"font-size: 12px;\">,&nbsp;</em><span style=\"font-size: 12px;\">str.18, ISSN 1338-1024.).</span></p>

Kľúčové slovo: 
metabolický profil buniek
malé molekuly
Pojem: 
Kontrastná látka
Definícia: 

<p>
Je r&aacute;diologick&yacute; term&iacute;n, ktor&yacute; sa použ&iacute;va pre tekutiny, plyny alebo tuh&eacute; substancie, ktor&eacute; zlep&scaron;uj&uacute; kontrast a vz&aacute;jomn&uacute; odl&iacute;&scaron;iteľnosť dvoch org&aacute;nov alebo tkan&iacute;v. Ich spektrum je veľmi &scaron;irok&eacute; a využ&iacute;vaj&uacute; sa vo v&scaron;etk&yacute;ch z&aacute;kladn&yacute;ch zobrazovac&iacute;ch met&oacute;dach. Z&aacute;kladnou podmienkou ich použitia je bezpečnosť pre človeka.</p>

Kľúčové slovo: 
kontrast
zobrazovacie vyšetrenie
Pojem: 
Jódová kontrastná látka
Definícia: 

<p>
Je neionick&aacute; kontrastn&aacute; l&aacute;tka aplikovan&aacute; do perif&eacute;rnej žily v&nbsp;priebehu CT angiografick&eacute;ho vy&scaron;etrenia, za &uacute;čelom zobrazenia mozgov&yacute;ch, krčn&yacute;ch, hrudn&yacute;ch, bru&scaron;n&yacute;ch, panvov&yacute;ch tepien ako aj tepien končat&iacute;n. Kontraindik&aacute;ciou vy&scaron;etrenia je pozit&iacute;vna alergick&aacute; anamn&eacute;za na j&oacute;dov&eacute; prepar&aacute;ty, relat&iacute;vnou kontraindik&aacute;ciou zn&iacute;žen&aacute; funkcia obličiek. Vy&scaron;etrenie nevyžaduje žiadnu &scaron;peci&aacute;lnu pr&iacute;pravu, pred vy&scaron;etren&iacute;m sa nesmie 6 hod&iacute;n jesť.</p>

Kľúčové slovo: 
jód
kontrastná látka
CT
Pojem: 
Kontrastná látka v magnetickej rezonancii
Definícia: 

<p>
Jedn&aacute; sa najm&auml; o&nbsp;zl&uacute;čeniny gadol&iacute;nia, ktor&yacute;ch z&aacute;kladnou vlastnosťou je, že sa cielene nevychyt&aacute;vaj&uacute; v&nbsp;žiadnom type buniek a&nbsp;&scaron;&iacute;ria sa tak v&nbsp;cievnom riečisku a&nbsp;telov&yacute;ch tekutin&aacute;ch. Možno ich rozdeliť na l&aacute;tky s&nbsp;n&iacute;zkou a&nbsp;vysokou molekul&aacute;rnou hmotnosťou. Najbežnej&scaron;ie použ&iacute;van&yacute;mi s&uacute; n&iacute;zkomolekul&aacute;rne paramagnetick&eacute; chel&aacute;ty gadol&iacute;nia. Jednou z najd&ocirc;ležitej&scaron;&iacute;ch vlastnost&iacute; kontrastnej l&aacute;tky a d&ocirc;vodom jej čast&eacute;ho pod&aacute;vania pri zobrazovan&iacute; centr&aacute;lnej nervovej s&uacute;stavy je schopnosť prenikať po&scaron;kodenou hematoencefalickou bari&eacute;rou. Typicky sa napr&iacute;klad použ&iacute;vaj&uacute; pri zobrazovan&iacute; n&aacute;dorov, resp. pri MR angiografii.</p>

Kľúčové slovo: 
MR
kontrastná látka
Pojem: 
Gestačný vek plodu
Definícia: 

<p>
Znamen&aacute; trvanie tehotenstva meran&eacute; od prv&eacute;ho dňa poslednej men&scaron;tru&aacute;cie. Gestačn&yacute; vek sa ud&aacute;va ako počet dovŕ&scaron;en&yacute;ch dn&iacute; alebo t&yacute;ždňov.</p>

Kľúčové slovo: 
vek
plod

Stránky